Mammals including human beings have ability to maintain their internal environments, such as body temperature, oxygen concentration, blood pressure, blood glucose and so on within certain range, in order to survive in the environment on the earth.
   This relative constancy of the internal environments in mammals is called homeostasis. How can we maintain our internal environments ?
Autonomic nervous system and endocrine system are involved in maintaining homeostasis of internal environments such as body temperature, oxygen concentration, blood pressure, blood glucose and so on. Actually, autonomic nervous system and endocrine system cooperate to maintain homeostasis of the internal environments.
  Therefore, if you determine changes in activities of autonomic nerves innervating each organ/tissue by electrophysiological method after giving a material per os, appling a material on the skin, olfactory stimulation with scent of a material, you can find the function (activity) of the material (substance) as foods, drugs, cosmetics and essential oils.

However, the technique detecting changes in autonomic nerve activities in rats and mice by an electrophysiological method is very difficult to be mastered. Therefore, our company, ANBAS Corporation, is the only one company which is able to determine activities of autonomic nerves innervating organs and tissues in rats and mice in the world.
   This technique was originally established by Dr. Akina Niijima (Professor Emeritus, Niigata University, former Professor of Physiology, Medical School of Niigata University). Since we were directly trained by Professor Akira Niijima, we can pick up autonomic nerve fibers, which projected to a certain organ or tissue, on an electrode and detect the change in the activity of the autonomic nerve fibers under an anesthetized condition.
   The technique is illustrated in the following slide (next page).
   The autonomic nervous system is composed of the sympathetic nerves and parasympathetic nerves, which are illustrated in the slide .
   The relationships between changes in the autonomic nerves and physiological functions are shown in the table in the slide .